Diuretic activity of whole plant extract of Leptadenia pyrotechnic

In the Indian traditional medicine, Leptadenia pyrotechnica (Apocynaceae) whole plant is claimed to possess powerful diuretic activity. The aim of this study was evaluate potential methanol extract (MELP) in male albino rats. Group I, Control (2% CMC saline solution, 10 ml/kg, b.w), II, serves as a standard drug furosemide (10 mg/kg b.w) and different concentrations LP (100, 200 400 were intraperitoneally administered (n = 3 per each treatment group) hydrated rats their urine output monitored over period 5 h after administration. responses with its electrolyte excretion potency highly remarkable comparison control animals. MELP at dose shows significant increase volume Na+ accompanied by K+ dependent manner. This suggests that active component L.P. had similar effect furosemide. These results validate use agent.